In a mouse model, chronic inflammation was induced by injection of 1% carrageenan solution. The results summarized in Figure 1 below clearly show a reduction in the swelling of the paw for the OligoFlex treated group, compared with a negative control (glucose solution), while glucosamine fails to decrease swelling, relative to the glucose control6.
FIGURE 1: CHANGE IN KNEE SWELLING AFTER
CHEMICALLY
INDUCED INFLAMMATION
Pain relief in rats
Mono-iodoacetate (MIA) is a recognized rat model for predicting a compound’s
anti-arthritic effect in humans. In this study, the force of the hind paw
was used to assess the amount of inflammation and damage to the joint.
The results summarized in Figure 2 show that OligoFlex is comparable to
Ibuprofen in relieving the pain associated with inflammation and joint
degeneration after 21 days6 following MIA injection in the joint on Day
1.
FIGURE 2: PAW WITHDRAWAL FORCE 21 DAYS AFTER
TREATMENT
WITH MIA
6 OligoFlex® unpublished in vivo efficacy data on file at Diversified Natural Products.
